Avishield IBD INT

Attenuated live Avian Infectious Bursal Disease virus (IBD), IM strain VMG 91 104-105TCID50**
*TCID50 = 50% Tissue Culture Infective Dose
For active immunisation of chickens with maternally derived antibodies (MDA) to prevent mortality and clinical disease due to infection caused by Avian Infectious Bursal Disease (IBD) viruses. Chickens can be vaccinated from 8 days of age (please refer to section Amounts to be administered and administration route.). Indications
Do not use in unhealthy birds. Contraindications
No undesirable effect has been observed after vaccination. If you notice any serious effects or other effects not mentioned in this package leaflet, please inform your veterinary surgeon. Adverse reactions
Chickens. Target species
One dose of vaccine should be administered to each chicken in drinking water, or by the oculonasal route. The vaccine is safe for use in chickens from 8 days of age. Where the number of chickens is between the standard dosages, the next higher dosage should be used. Age for vaccination should be determined at the discretion of a veterinary surgeon taking into account level of maternally derived antibody (MDA) in the birds to be vaccinated (usually between the ages 10 to 20 days) because high levels of MDA can neutralise vaccine’s antigen. To predict the age when MDA titer has sufficiently decreased to allow effective vaccination (“break-through titre” for intermediate strains), testing of serum samples of at least 18 chicks by serology and application of the “Deventer Formula” is advised. Single vaccination, in general, provides a sufficient level of protection against Infectious Bursal Disease. In unfavourable epizootological conditions, and in flocks with various titre values of MDA, it is recommended to immunize chickens twice.

1. Administration in the drinking water
Suspend the vaccine in cool and clean water without traces of chlorine, other disinfectants or impurities in a number of doses corresponding to the number of birds to be vaccinated. Vaccine should be suspended immediately before use. Measure the correct volume of water for the number of birds to be vaccinated. The volume of water for reconstitution depends on the age of the birds, breed, management practice and weather conditions. Vaccine should be dissolved in the amount of water which will be drunk within 1.5 to 2.5 hours (taking into account the different types of drinking systems for poultry). In order to determine the quantity of water in which vaccine will be suspended, measure the volume of water consumed within a two hours period one day before vaccination. As an orientation guide for younger chickens (until 3rd week of life), apply reconstituted vaccine to cold and fresh water at the rate of 1,000 doses of vaccine to 1 litre of water per day of age for 1,000 chickens, e.g. 8 litres would be needed for 1,000, 8 day old chickens. In order to make the birds thirsty, withdraw the supply of drinking water up to 2 hours prior to immunisation (birds drinking behaviour varies, depending on the air temperature, type of birds, breed, management, weather conditions). The drinking system should work properly and should be clean, without traces of chlorine, other disinfectants or impurities.
For animal treatment only Under supervision of Veterinary Organization If needed, turn the lights down low when the water is turned off. After vaccine is in drinking system, increase light. Increased light intensity will stimulate the birds to look for food and water. Always make sure that there is food available when vaccinating. Birds will not drink if they have no food to eat. Once the vaccine has been consumed, resume management practices as normal. This approach to vaccination will ensure a more even vaccination of the flock and will be less stressful to the birds. Performance should therefore be less adversely affected.

2. Oculonasal Administration
Suspend 1000 doses of the vaccine in 100 ml distilled water. A dose of reconstituted vaccine is 0.1 ml, i.e. two drops, irrespective of poultry age, weight and type. Instil one drop into the eye and one drop into the nose opening.
Administration & dosage
All the birds in the flock should be vaccinated at the same time. Advice on correct administration
Zero days. Withdrawal period
Special warnings for each target species:
In any population of animals there are individuals who respond poorly to vaccination. Immune responses affect depend on hereditary factors, subclinical diseases, physical condition, stress, concomitant use of other veterinary medicinal product, and whether the vaccine was appropriately stored and applied. It is particularly important that in the period after vaccination birds are properly kept and fed. The vaccine strain can spread to susceptible, unvaccinated chickens for at least 10 days following vaccination without inducing clinical signs.

Special precautions for use in animals:
All the birds in the flock should be vaccinated at the same time.

Special precautions to be taken by the person administering the veterinary medicinal product to animals:
Wash and disinfect hands and equipment after vaccination.
Keep out of the sight and reach of children. Store and transport refrigerated (2 ºC - 8 ºC). Protect from light. Do not freeze. Do not use this veterinary medicinal product after the expiry date which is stated on the label and carton. Shelf life after reconstitution: 3 hours. Storage
Daru Dam Karoon Trading/ Tajeran Mehr Samanian No 11, Parcham St., Towhid Sq., Tehran, Iran
Tel: +98 21 66930113 Fax: +98 21 66934916