Avishield ND B1

Live, lentogenic virus of Newcastle disease, strain Hitchner B1 106-107TCID50**
*TCID50 = 50% Tissue Culture Infective Dose
For active immunisation of chickens and turkeys to prevent mortality, clinical signs and lesions of the Newcastle disease. Indications
Do not use in unhealthy birds. Contraindications
Respiratory disturbances such as tracheal rales may occur after intranasal/ocular route of administration. These signs could last at least two weeks. If you notice any serious effects or other effects not mentioned in this package leaflet, please inform your veterinary surgeon. Adverse reactions
Chickens and turkeys. Target species
The vaccine can be used in three ways - oculonasally, in drinking water and spray. Method of application depends on the epizootiological situation, age category and number of animals. Vaccine can be administered to day old chicks and older chickens by coarse spray or by the oculonasal route of administration. Chickens can be vaccinated by the in-water route once birds are shown to be drinking well from the drinker system in use. Turkeys can be vaccinated from 14 days of age by coarse spray, by the oculonasal route of administration or by the drinking water route. Where the number of birds is between the standard dosages, the next higher dosage should be used. Under adverse epizootiological situation it is necessary to repeat vaccination with the same vaccine or an inactivated vaccine.

1. Oculonasal Administration
Suspend 1000 doses of the vaccine in 100 ml distilled water. A dose of reconstituted vaccine is 0.1 ml, i.e. two drops, irrespective of poultry age, weight and type. Instil one drop into the eye and one drop into the nostril.

2. Administration in the drinking water
Suspend the vaccine in cool and clean water without traces of chlorine, other disinfectants or impurities in a number of doses corresponding to the number of birds to be vaccinated. The vaccine should be suspended immediately before use. Measure the correct volume of water for the number of birds to be vaccinated. The volume of water for reconstitution depends on the age of the birds, breed, management practice and weather conditions. In order to determine the quantity of water in which vaccine will be suspended, measure the volume of water consumed within a two hours period one day before vaccination. The vaccine should be dissolved in the amount of water which will be drunk within 1.5 to 2.5 hours (taking into account the different types of drinking systems for poultry). As an orientation guide for younger chickens (until 3rd week of life), apply reconstituted vaccine to cold and fresh water at the rate of 1,000 doses of vaccine to 1 litre of water per day of age for 1,000 chickens, e.g. 7 litres would be needed for 1,000, 7 day old chickens In order to make the birds thirsty, withdraw the supply of drinking water up to 2 hours prior to immunisation (birds drinking behaviour varies, depending on the air temperature, type of birds, breed, management, weather conditions). The drinking system should work properly and should be clean, without traces of chlorine, other disinfectants or impurities. If needed, turn the lights down low when the water is turned off. After vaccine is in drinking system, increase light. Increased light intensity will stimulate the birds to look for food and water. Once the vaccine has been consumed, resume management practices as normal. This approach to vaccination will ensure a more even vaccination of the flock and will be less stressful to the birds. Performance should therefore be less adversely affected.

3. By spraying
It is recommended to resuspend 1000 doses of the vaccine in 150 - 300 ml of distilled water. The number of doses diluted corresponds to the number of birds in a flock. The volume of water for reconstitution should be sufficient to ensure an even distribution when sprayed onto the birds, and will vary according to the age of the birds being vaccinated and the management system. The reconstituted vaccine suspension should be spread evenly over the correct number of chickens, at a distance of 30 – 40 cm using a coarse spray, preferably when the chickens are sitting together in dim light. Administration by spraying is recommended for a rapid onset of solid immunity or in case of direct flock exposure to the disease. In case of vaccination by spraying, day-old chickens are best vaccinated in hatchery or during moving in poultry house. Older categories are recommended vaccinated in a smaller space (floor breeding), or the vaccine is sprayed directly on birds kept in cages. Prior to vaccination, it is necessary to switch off the aeration system.
Administration & dosage
All the birds in the flock should be vaccinated at the same time. Advice on correct administration
Zero days. Withdrawal period
Special warnings for each target species:
In any population of animals there are individuals who respond poorly to vaccination. Immune responses affect depend on hereditary factors, subclinical diseases, physical condition, stress, concomitant use of other veterinary medicinal product, and whether the vaccine was appropriately stored and applied. It is particularly important that in the period after vaccination birds are properly kept and fed. The vaccine strain can spread to susceptible, unvaccinated birds for at least 10 days following vaccination. The spread does not induce clinical signs.
Special precautions for use in animals:
All the birds in the flock should be vaccinated at the same time
Special precautions to be taken by the person administering the veterinary medicinal product to animals:
Care should be taken when handling and administering the vaccine. Newcastle disease virus can cause a mild transient conjunctivitis in the person administering the vaccine. Well-fitting masks and eye protection should be worn when handling the product. Hands should be washed and disinfected after vaccinating.
Zero days. Withdraval period
Keep out of the sight and reach of children. Store and transport refrigerated (2 ºC - 8 ºC). Protect from light. Do not freeze. Do not use this veterinary medicinal product after the expiry date which is stated on the label and carton. Shelf life after reconstitution: 3 hours. Storage
Daru Dam Karoon Trading/ Tajeran Mehr Samanian No 11, Parcham St., Towhid Sq., Tehran, Iran
Tel: +98 21 66930113 Fax: +98 21 66934916